News story: Expert Advisory Group set-up to review paclitaxel drug-coated balloon catheters and drug-eluting stents

first_imgThis page has been withdrawn as we have now updated the guidance.,Following recently published findings by Katsanos et al raising concerns over the use of paclitaxel eluting balloons and stents in the treatment of patients with peripheral arterial disease (PAD) and in particular the femoropopliteal artery in the leg.We have formed an independent Expert Advisory Group (EAG). The EAG has begun the process of reviewing the available, but highly complex information on these medical devices. The group is made up of leading UK clinicians from specialist societies, including interventional radiology, vascular surgery and scientists with toxicology, medicines and statistical expertise.The publication suggests a possible increased mortality rate from 2 up to 5 years in PAD patients treated with paclitaxel-coated balloons and paclitaxel-eluting stents. This is compared to patients treated with non-coated balloons or bare metal stents. A causal relationship for this observation has not been identified and may reflect limitations in the way the data were analysed, but this has yet to be determined.Patient safety is our highest priority and we take information questioning the safety of any medical device very seriously. Since the publication we have been collecting and analysing information from a range of sources to try to understand the significance of the findings for future patient treatment options.The devices in question have valid CE certificates and remain on the UK market. The outcome of our investigation will determine if new advice is required or if we need to undertake any other regulatory action.The EAG has been asked to consider whether the publication’s findings and device-specific clinical study results are statistically robust and whether there is any evidence of a causal relationship between the drug, paclitaxel, and increased mortality.There are a number of other publications which put forward different results and opinions taking into account other factors such as the overall health of the patient.To assist them they have been provided with the full spectrum of source material available to MHRA, together with all relevant published information we have gathered. The aim is to provide a greater understanding of the potential benefits and risks to patients and will help to guide any possible future MHRA action.The EAG has agreed to undertake and complete their review, including reporting their findings to MHRA, within the next few months.Additionally, we are collaborating with the major clinical and regulatory stakeholders, including the British Society of Interventional Radiology (BSIR), the UK Basil-3 trial and NICE, as well as other European and global regulatory authorities.If you are worried that you might be affected by this matter, we advise you to contact your GP or specialist.last_img read more

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Press release: Big wins for British businesses as Vice Premier Hu Chunhua visits

first_img Redington’s Chinese subsidiary, Yuyuan Technology has signed commercial agreements with Taikang Life and Aviva-Cofco Life to provide interactive asset liability management tools. Micro Focus, one of the UK’s largest listed technology companies, announced a series of partnership deals with Chinese company H3C, marking its continued expansion into the Chinese market. The deals were signed and agreed at a ceremony at Mansion House, witnessed by Minister for Trade Policy, George Hollingbery MP.An MoU was also signed between DIT and the National Development and Reform Commission of the People’s Republic of China on infrastructure cooperation in third countries.This is a technical agreement that focusses on facilitating practical cooperation between UK and Chinese firms on projects overseas – ensuring that projects are delivered in line with the highest economic, environmental, social and financial standards in order to deliver sustainable, and inclusive development outcomes and deliver real opportunities for UK and international businesses.Further information on commercial deals and MoUs:Deals valued at £503 million have been agreed, creating 175 new jobs.Financial Services Creative OakNorth, Baillie Gifford and VCP Advisors have announced that they will set up a Wholly Foreign-Owned Enterprise (WFOE) in China. MultiPass International and UnionPay International concluded an MoU to develop a digital payment platform to further expand issuance and acceptance of UnionPay branded cards outside mainland China. The new partnership is expected to create 105 new jobs over the next 3 years. New business deals representing commercial signings, future contract commitments and MoUs, were agreed by British and Chinese companies as part of the 10th UK China Economic and Financial Dialogue (EFD) taking place in London this week.The announcements were welcomed by the International Trade Secretary, Dr Liam Fox MP.In total, the deals are expected to deliver 175 new jobs in the UK, and deliver significant wins for the financial services, education, creative, food and agriculture and technology sectors.Also announced today was a landmark market access agreement for British farmers, supported by the Department for International Trade (DIT) and the Department for Environment, Food and Rural Affairs (Defra), which could put UK producers on track to export British beef to China by the end of 2019.The agreement is expected to be worth an estimated £230 million in the first 5 years.Secretary of State for International Trade, Liam Fox MP, said: China Industrial Bank announced plans for a new representative office in London. The London Representative Office is expected to become an important base for the global initiatives of Industrial Bank. Education XTX markets will become the first foreign non-bank market maker on the CFETS’s G10 market. Wonderbly a UK publishing and education technology company, has signed an MoU for strategic cooperation with China’s biggest publishing group – Phoenix Publishing and Media Group to bring innovative personalised reading and learning to the Chinese market Energy and Built Environment Schroders have been awarded Qualified Foreign Limited Partner (QFLP) licences and quotas. UK engineering consultancy company Arup and Shanghai Urban Construction Design & Research Institute (SUCDRI) have signed and MoU to cooperate on future infrastructure projects. The MoU follows a recently successful joint bid by the two organisations for the Shanghai Central Urban Area Drainage Masterplan project from Shanghai’s municipal government. Cranleigh School and Cogdel Education Group signed an MoU lasting 25 years denoting a partnership to set up Cranleigh’s bilingual school in China. Techcenter_img A new UK-China Fund, targeting £1 billion delivered in partnership by Charterhouse Capital, China Investment Corporation and HSBC to invest in UK SMEs with growth plans linked to China. Export wins for Hayman’s range of Gins; London Distillery; McCann Apples; Rooney Fish; Newby Tea and Baijiu Society. Innovative Physics Limited (IPL) and CNNC Environmental Protection Co. (CEPC) have signed a collaboration framework agreement. Hayward Tylor (HT) have signed an MoU agreement with Shinhoo Canned Motor Pumps (SH) to supply pumps for the energy and chemical industry. BBC Studios announced a wide-ranging partnership with Promotional Partners Worldwide (PPW), to bring British children’s cartoon ‘Hey Duggee’ to China . The agreement will see PPW act as the agent and licensee for Hey Duggee for Greater China – including mainland China, Taiwan, Hong Kong and Macau. China Banking Association, Shanghai Stock Exchange, China Investment Corporation (CIC), The Industrial Bank and CITIC Bank have announced they will be upgrading existing branches, opening representative offices or opening new branches in the UK. Cornwall’s The Lost Gardens of Heligan, one of the UK’s most well-known gardens, has announced a collaboration with Sheng lu Manor in Beijing to create a “Beijing Shenglu Heligan Garden’, to showcase the UK’s cultural, agronomic and horticulture expertise. Britain is a key partner for Chinese trade and investment, and is one of China’s most important trading partners in Europe. Today’s announcements show the breadth and depth of our trading relationship, the success UK firms are having in China, and the huge opportunity the Chinese market holds for British companies, particularly with regards to market access. As an international economic department, DIT will continue to support UK businesses to increase their share in this growing market and build on our substantial export figures, as we progress towards leaving the EU. Thames Holdings Ltd and Shenzhen Fuzhida Management Ltd, signed a contract to form a joint venture to establish 50 nurseries across China in next 5 years. Repton and Kingold have signed an MOU to set up Repton’s billingual schools initially in the Greater Bay Areas. Establishment of Heng’An Standard Life’s (HASL) pension insurance business, the first awarded to a foreign- invested business in China. Food and Drink China National Petroleum Cooperation (CNPC), along with its joint venture partner INEOS, will invest in a New Energy Project in steam and electric power, at the Grangemouth facility. The plant will operational by 2022. Bilateral trade between the UK and China is worth a record £68.5 billion a year, the UK’s fifth-largest trading relationship.Over the past decade UK exports to China have tripled, making China the UK’s sixth largest market globally with more than 10,000 UK businesses now selling goods and services to China.last_img read more

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Detailed guide: Local COVID alert level: very high (Greater Manchester)

first_imgNorth East South West Yorkshire and The Humber North West replaced by National lockdown – Stay at Home,Decisions on which area goes into which tier are primarily based on 5 key epidemiological indicators: Cumbria Greater Manchester Lancashire, Blackburn with Darwen, and Blackpool Warrington and Cheshire Region Herefordshire Shropshire, and Telford and Wrekin Worcestershire Bath and North East Somerset Bristol Cornwall Devon, Plymouth and Torbay Dorset North Somerset South Gloucestershire Wiltshire City of York and North Yorkshire The Humber: East Riding of Yorkshire, Kingston upon Hull/Hull, North East Lincolnshire and North Lincolnshire South Yorkshire (Barnsley, Doncaster, Rotheram, Sheffield) West Yorkshire (Bradford, Calderdale, Kirklees, Leeds, Wakefield) West Midlands East of England Derby and Derbyshire Leicester City and Leicestershire Lincolnshire Northamptonshire Nottingham and Nottinghamshire Liverpool City Region Tier 4: Stay at HomeEast Midlands Rutland North Westcenter_img West Midlands North East Combined Authority (this area includes the local authorities of County Durham, Gateshead, South Tyneside and Sunderland) North of Tyne Combined Authority (this area includes the local authorities of Newcastle-upon-Tyne, North Tyneside and Northumberland) Tees Valley Combined Authority (this area includes the local authorities of Darlington, Hartlepool, Middlesbrough, Redcar and Cleveland, and Stockton-on-Tees) London case detection rates in all age groups case detection rates in the over-60s the rate at which cases are rising or falling positivity rate (the number of positive cases detected as a percentage of tests taken) pressure on the NHS Berkshire Brighton and Hove, East Sussex and West Sussex Buckinghamshire Hampshire, Southampton and Portsmouth Isle of Wight Kent and Medway Oxfordshire Surrey Bedford, Central Bedfordshire, Luton and Milton Keynes Cambridgeshire Essex, Southend-on-Sea and Thurrock Hertfordshire Norfolk Peterborough Suffolk All 32 London boroughs plus City of London Bournemouth, Christchurch and Poole Gloucestershire (Cheltenham, Cotswold, Forest of Dean, Gloucester City, Stroud and Tewkesbury) Somerset (Mendip, Sedgemoor, Somerset West and Taunton, and South Somerset) Swindon South East Tier 2: High alertNo areas are currently in Tier 2.Tier 3: Very High alertEast Midlands Isles of Scilly South West Birmingham, Dudley, Sandwell, Walsall and Wolverhampton Coventry Solihull Staffordshire and Stoke-on-Trent Warwickshire The indicators are designed to provide a full picture of what is happening with the virus in any area so that suitable action can be taken.Each bullet point on this list constitutes an ‘area’ for the purposes of guidance.Find out more information on tiers, including what you can and cannot do in each tier.Tier 1: Medium alertSouth Westlast_img read more

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Businesses going bust increase in double-dip recession

first_imgThe number of retailers going out of business has risen by 38% in the first quarter of 2012, according to accountancy firm Wilkins Kennedy.The latest statistics from the firm revealed 680 companies went bust during the first three month of the year, up from 486 in the fourth quarter 2011.Anthony Cork, partner at Wilkins Kennedy, said: “Last year was bad but this year is even worse. Retailers are still struggling with rents that they feel are far above the market rate and banks are particularly reluctant to extend credit to struggling retail businesses.“The double-dip has pulled the retail sector down sharply. It is hard to see consumer spending rebounding in the current environment of slow wage growth and worries over the Eurozone.”Some of this year’s high street retailer casualties have included discount clothing retailer Peacocks, The Game Group and Clinton Cards.The Office for National Statistics (ONS) additionally reported slumping retail sales figures for April last week, highlighting zero growth in total sales values, excluding fuel, compared with April 2011 – meaning a real-terms fall. This compares with a 1% decline recorded for the same period by the British Retail Consortium’s (BRC) own figures earlier this month.Stephen Robertson, director general at the BRC, said:”April sales were always going to struggle against a strong performance a year ago helped by better weather, a later Easter and an extra bank holiday then but real-terms sales declines are bad news. Falling inflation offers some hope for customers but disposable incomes are still dropping and people are not spending on things that aren’t immediate needs.”Retailers are hoping the return of sun in the last few days and the build- up to this summer’s big events produces a much- needed lift in the public mood but a fundamental turnaround remains illusory.”last_img read more

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Lidl continues with ISB roll-out

first_imgLidl has confirmed its intentions to roll out in-store bakeries to all its UK outlets, should the success it has seen so far continue.The discount retailer has reportedly already rolled the concept out to around 340 of its 600 UK stores.A spokesperson for Lidl said that, in response to customers’ increasing focus on fresh food, it had been trialling in-store bakeries in several UK regions over the past 12 months to gauge customer feedback.“So far, the in-store bakeries have been a huge hit with customers and, if the next batch of in-store bakeries proves to be just as successful this year, then we will roll them out nationwide.”In August 2011, British Baker reported that the German retailer had installed ISBs in 75 stores in its north-east sales region, bringing its total number of outlets with ISBs in the UK to 90.last_img read more

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Food inflation stable at 3.5% in March

first_imgThe British Retail Consortium (BRC) has said it expects food inflation to remain steady in the medium-term.It comes as the rate of inflation remained unchanged in March, at 3.5%, while overall shop price inflation rose to 1.4% during the month, in comparison to 1.1% in February.Helen Dickinson, director general of the BRC, said: “Food inflation is unchanged since February, but this is primarily due to a decrease in prices for tinned and packet goods balancing out a fresh food rise. There are still price pressures, which will continue to work through, but I would expect food inflation to remain fairly steady in the medium term. “Total inflation is at its highest rate since December, again reflecting that many retailers went into the New Year with less stock to clear, so discounting is less extensive compared with 2012.”Mike Watkins, head of retailer and business insight, Nielsen said: “With cold weather in March holding back spending across many channels, price reductions have been needed to stimulate demand for food and there was also an increase in price competition at the supermarkets due to Easter promotions, keeping overall food inflation stable.“As discretionary spend for the next few months is expected to remain flat at best, what upward pressure there is on prices is not coming from the consumer at the moment.”Last October, food inflation rose to 4%, a 0.9% rise on the previous month when the rate was at a two-year low. The BRC said it had been affected by poor harvests, rising production costs and commodity price increases.last_img read more

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New café at original Pieminister site

first_imgPieminister has launched a new café and dining concept at a site where the business started 10 years ago, in Stokes Croft, Bristol.The pie business, founded by Jon Simon and Tristan Hogg, has invested £200,000 in the new bistro-style bar and all-day café shop, which includes a bar stocking local craft beers and ciders.The outlet will also be the first to serve Pieminister’s mash-topped pies, which will be served in enamel tins and come in three different varieties: fish pie, cottage pie and pulled pork pie.Pieminister said the site extends back into its old pie kitchens, which has doubled the size of the dining space, and will operate from 10am until 11pm to cater for a number of eating occasions, including breakfast and afternoon tea.Simon said: “Being able to buy our North Bristol pie kitchens in 2012 was a landmark moment for us. It meant we could move forwards and focus on reinvesting in Bristol. Making Pieminister’s birthplace our permanent home feels fantastic and we’re excited to be back in the heart of Stokes Croft.”As part of the financial investment, a new office space has been developed above the café and shop, which will house the company’s marketing, events and sales teams. In addition, 13 new members of staff were hired for the new café, adding to Pieminister’s current workforce at the Stokes Croft site, where more than 40 employees currently work.Last September, the firm acquired its four-acre manufacturing site in Bristol, thanks to a seven-figure funding package from HSBC.This February, Pieminister revealed a 28% increase in sales to £8.3m in the year to 31 March 2012, as part of its latest financial reports filed at Companies House last month.last_img read more

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New marketing head at SSP UK

first_imgSSP UK has appointed Lucy Knowles as its new chief marketing officer, responsible for brands such as Upper Crust, Caffè Ritazza and Millie’s Cookies.The firm, which operates restaurants and cafés in railway stations and airports across the country, revealed Knowles will take up the new role on 20 May and will form part of SSP UK’s executive board.She will implement a long-term strategic plan, including developing new products, acquisitions and joint ventures and other growth initiatives as part of her remit.Knowles, who previously worked as managing director for Corney & Barrow Bars, said: “I am hugely excited by the opportunity to be part of the team at SSP and look forward to contributing to the company’s continued success.”Mark Angela, chief executive of SSP UK, said: “Lucy brings with her a drive and charisma that has characterised her career at Corney & Barrow coupled with a natural marketing instinct. We’re delighted to welcome her to SSP.”last_img read more

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Raising agents firm gains US distributor

first_imgKudos Blends, the leading supplier of technically driven raising agents, has secured a distributor for its products in the USA.The Shropshire-based business has a signed a deal with Brenntag North America, which it said will “expand the reach of Kudos’ low sodium solutions for baked goods throughout the United States and provide quality local support to existing customers”.Brenntag North America will be responsible for the distribution of Kudos Potassium Bicarbonate, a product developed as an alternative to sodium bicarbonate to aid bakers in reducing sodium content without removing salt.Dinnie Jordan, chief executive of Kudos Blends, said: “As the demand for sodium reduction solutions increases across the globe, it is important for Kudos as an industry leader to be able to meet customers’ needs and provide them with the products and knowledge they need on a local scale.Brenntag“Brenntag was the ideal choice for us, due to its proactive approach and focus on understanding their customers. A strong and fruitful partnership is sure to be developed with Brenntag and they are a welcome addition to our team.”Leslie Darden, marketing director, Brenntag North America, added: “Brenntag is committed to bringing innovative solutions to our customers. Kudos brings patented technology and a commitment to continuous innovation that will bring technical expertise to our customers. We are excited for this partnership and believe the Kudos product line is an excellent addition to our product portfolio.”last_img read more

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Scotch Pie Championship attracts record entries

first_imgA record number of Scotland’s bakers have entered their best pies into the 16th World Scotch Pie Championships.Judges considered more than 600 pies from 100 of the country’s butchers and bakers, and will announce the winner of the title this coming January.Contestants also entered sausage rolls, speciality savouries, Scottish football pie, apple pie and savouries.Les McKeown, original lead singer of The Bay City Rollers and the competition’s guest pie taster, said: “I was honoured to be asked to join the panel of judges again for this iconic competition. The contest is a hard-fought one and in each category we are looking for something really special that stands out from the crowd.” Last year the 2014 title was taken by Stephen McAllister from The Kandy Bar of Saltcoats.last_img read more

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